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KMID : 0362420110490030254
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Journal of Korean Academy of Prosthodontics
2011 Volume.49 No. 3 p.254 ~ p.262
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Review of the developmental trend of implant surface modification using organic biomaterials
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Hwang Sung-Taek
Han In-Ho
Huh Jung-Bo
Kang Jeong-Kyung
Ryu Jae-Jun
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Abstract
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Purpose: This study aims to evaluate and prospect for current research trend and developmental perspectives via analyzing recent biomaterial coated-implants study.
Materials and Methods:To investigate each subject respectively, several biomaterials that are using for implant surface coating were set as‘ keywords’. By these keywords, major research groups in each subject were chosen, and research trend of them was analyzed. Trend of In vivo studies that examined selected biomaterials were analyzed to evaluate commercial potential.
Results:The collagen research accounted for 40% of total implant study, which was the highest, and fibronectin, BMPs (bone morphogenetic proteins) and RGD (Arg-Gly-Asp) peptides followed, which were ranked in descending order. Furthermore, figures of all four research subjects were also increased with time, especially a sharp increase in RGD research. According to the results of major research group, collagen that was combined with other organic and inorganic biomaterials was mostly examined, rather than using collagen only. Major research groups investigating BMPs mostly focused on rhBMP-2. In animal studies, collagen was used as resorbable membrane in guided bone regeneration (GBR) or drug carrier, while BMPs were used with bone graft materials or coating material for titanium implant surface.
Conclusion: There is not consistency of results even in identical subjects research field. Many studies are ongoing to optimize combination between mechanical surface treatment and biomaterials such as extracellular matrix component and growth factors.
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KEYWORD
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Dental implant, Surface modification, Biomolecule, Extracellular matrix, Growth factor
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